Published Research Library
Navigate through this online library resource to see firsthand how Photometrics cameras support the sophisticated imaging requirements for a multitude of cutting edge research applications.
- January 2012

American Journal of Stem Cells
Towards high throughput tissue engineering: development of chitosan-calcium phosphate scaffolds for engineering bone tissue from embryonic stem cells
Camera used: CoolSNAP HQ2
Methods in Molecular Biology
A Live Cell Micro-imaging Technique to Examine Platelet Calcium Signaling Dynamics Under Blood Flow
Camera used: QuantEM
Methods in Molecular Biology
Monitoring Integrin Activation by Fluorescence Resonance Energy Transfer
Camera used: QuantEM - December 2011

Nature Methods
Bayesian localization microscopy reveals nanoscale podosome dynamics
Camera used: Cascade II 1024 - November 2011

JCI (Journal of Clinical Investigation)
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease
Camera used: CoolSNAP HQ2
G3 (Genes Genomes Genetics)
Double-Strand Break Repair and Holliday Junction Processing Are Required for Chromosome Processing in Stationary-Phase Escherichia coli Cells
Camera used: CoolSNAP HQ2
EMBO Journal (European Molecular Biology Organization)
Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest
Camera used: CoolSNAP HQ2
Nano Letters
Dynamic SERS Imaging of Cellular Transport Pathways with Endocytosed Gold Nanoparticles
Camera used: QuantEM
Journal of Immunology
Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1
Camera used: CoolSNAP ES2
Scientific Reports
Phosphatidylinositol 4, 5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity
Camera used: CoolSNAP HQ2
BMC Biotechnology
A bacteria colony-based screen for optimal linker combinations in genetically encoded biosensors
Camera used: QuantEM
Journal of Stroke and Cerebrovascular Diseases
Survival and Differentiation of Transplanted Neural Stem Cells Derived from Human Induced Pluripotent Stem Cells in A Rat Stroke Model
Camera used: CoolSNAP HQ2
PLoS ONE (Public Library of Science)
Dynamic Microtubules Promote Synaptic NMDA Receptor-Dependent Spine Enlargement
Camera used: CoolSNAP HQ2
Analytical Chemistry
FRET-based biosensors for multiparameter ratiometric imaging of Ca 2+ dynamics and caspase-3 activity in single cells
Camera used: QuantEM
JCB (Journal of Cell Biology)
Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis
Camera used: CoolSNAP HQ2
JOVE (Journal of Visualized Experiments)
Study of the Actin Cytoskeleton in Live Endothelial Cells Expressing GFP-Actin
Camera used: CoolSNAP HQ2
MBoc (Molecular Biology of the Cell)
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover
Camera used: QuantEM
American Journal of Physiology
Estradiol Attenuates High Glucose Induced Endothelial Nitrotyrosine: Role for Neuronal Nitric Oxide Synthase
Camera used: CoolSNAP HQ2
Journal of Neuroscience
The Human Immunodeficiency Virus Coat Protein gp120 Promotes Forward Trafficking and Surface Clustering of NMDA Receptors in Membrane Microdomains
Camera used: QuantEM
Microbes and Infection
A new vesicular compartment in Encephalitozoon cuniculi
Camera used: CoolSNAP HQ2
American Journal of Physiology
Estradiol Attenuates High Glucose Induced Endothelial Nitrotyrosine: Role for Neuronal Nitric Oxide Synthase
Camera used: CoolSNAP HQ2
Nature Methods
Visualizing mechanical tension across membrane receptors with a fluorescent sensor
Camera used: Evolve 512 - October 2011

Analytical and Bioanalytical Chemistry
Physisorbed surface coatings for poly (dimethylsiloxane) and quartz microfluidic devices
Camera used: QuantEM
Langmuir
QD-Antibody conjugates via carbodiimide-mediated coupling; a detailed study of the variables involved and a possible new mechanism for the coupling reaction under Basic
Camera used: QuantEM
Cell Metabolism
Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection
Camera used: Evolve 512
Journal of Neurophysiology
Inhibitory responses in Aplysia pleural sensory neurons act to block excitability, transmitter release and PKC Apl II activation.
Camera used: QuantEM
Journal of Cerebral Blood Flow & Metabolism
Fibrinogen-induced increased pial venular permeability in mice
Camera used: QuantEM
Journal of Microscopy
High‐resolution cell outline segmentation and tracking from phase‐contrast microscopy images
Camera used: CoolSNAP HQ2
Traffic
Protein trafficking rates assessed by quantum dot quenching with bromocresol green
Camera used: QuantEM
PNAS (Proceedings of the National Academy of Sciences)
Shared gene expression in distinct neurons expressing common selector genes
Camera used: CoolSNAP HQ2
Current Biology
Rapid De Novo Centromere Formation Occurs Independently of Heterochromatin Protein 1 in C. elegans Embryos
Camera used: QuantEM
Computerized Medical Imaging and Graphics
Molecular imaging of small animals with fluorescent proteins: From projection to multimodality
Camera used: CoolSNAP ES2
Talanta
A microsecond microfluidic mixer for characterizing fast biochemical reactions
Camera used: Evolve 512
Journal of Neuroscience
In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice
Camera used: QuantEM
Human Molecular Genetics
The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins
Camera used: QuantEM
Biophysical Journal
Initial Dynamics of Cell Spreading Are Governed by Dissipation in the Actin Cortex
Camera used: Evolve 512 - September 2011

Nature Cell Biology
Adaptive braking by Ase1 prevents overlapping microtubules from sliding completely apart
Camera used: QuantEM
Nature Communications
Microfluidic quadrupole and floating concentration gradient
Camera used: CoolSNAP HQ2
Nature Methods
Light-based feedback for controlling intracellular signaling dynamics
Camera used: Evolve 512
Biomedical Optics Express
Quantitative characterization of fluorophores in multi-component nanoprobes by single-molecule fluorescence
Camera used: QuantEM
The Plant Journal
Barley mildew and its elicitor chitosan promote closed stomata by stimulating guard - cell S - type anion channels
Camera used: QuantEM
Journal of Nanobiotechnology
Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism
Camera used: CoolSNAP ES2
Biotechnology Journal
Translocation of green fluorescent protein by comparative analysis with multiple signal peptides
Camera used: CoolSNAP HQ2 - August 2011

Journal of Trauma
Hypertonic Saline Resuscitation of Hemorrhagic Shock Does Not Decrease In Vivo Neutrophil Interactions With Endothelium in the Blood-Brain Microcirculation
Camera used: QuantEM
Nature Biotechnology
Quantitative fluorescence imaging of protein diffusion and interaction in living cells
Camera used: QuantEM
American Journal of Physiology
G protein-coupled estrogen receptor 1 (GPER)-mediated effects in the rat myometrium
Camera used: CoolSNAP HQ2
Biochemical Journal
Divergent effect of mammalian PLC-zeta in generating Ca2+ oscillations in somatic cells versus eggs
Camera used: CoolSNAP HQ2
British Journal of Pharmacology
Hydrophobic anions potently and uncompetitively antagonize GABAA receptor function in the absence of a conventional binding site
Camera used: CoolSNAP ES2
Biomaterials
Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4: Yb, Tm nanocrystals
Camera used: CoolSNAP HQ2
Molecular Pharmacology
Developing Chemical Genetic Approaches to Explore G Protein-coupled Receptor Function-Validation of the use of a Receptor Activated Solely by Synthetic Ligand (RASSL)
Camera used: CoolSNAP HQ2
MBoc (Molecular Biology of the Cell)
The filament-forming protein Pil1 assembles linear eisosomes in fission yeast
Camera used: CoolSNAP HQ2
JARO (Journal of the Association for Research in Otolaryngology)
TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells
Camera used: Evolve 512 - July 2011

Microcirculation
Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting (DqDF)
Multichannel System used: DV2
Diabetologia
Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice
Camera used: CoolSNAP HQ2
Journal of Neuroscience
Netrin-1-Induced Local β-Actin Synthesis and Growth Cone Guidance Requires Zipcode Binding Protein 1
Camera used: CoolSNAP HQ2
Biological Chemistry
Dynamics of septin ring and collar formation in Saccharomyces cerevisiae
Camera used: QuantEM
JBC (Journal of Biological Chemsitry)
Functional adaptation between yeast actin and its cognate myosin motors
Camera used: CoolSNAP HQ2
Circulation
Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes MellitusClinical Perspective
Camera used: CoolSNAP HQ2
PLoS ONE (Public Library of Science)
High-Resolution Quantification of Focal Adhesion Spatiotemporal Dynamics in Living Cells
Camera used: QuantEM
Cellular Physiology and Biochemistry
Homocysteine Induces Phosphatidylserine Exposure in Cardiomyocytes through Inhibition of Rho Kinase and Flippase Activity
Camera used: QuantEM
American Journal of Physiology
Reversal of Diabetic Vasculopathy in a Rat Model of Type 1 Diabetes by Opiorphin-Related Peptides
Camera used: CoolSNAP HQ2
JCB (Journal of Cell Biology)
Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping
Camera used: CoolSNAP HQ2
MBoc (Molecular Biology of the Cell)
MICAL-like1 mediates epidermal growth factor receptor endocytosis
Camera used: CoolSNAP HQ2
Current Biology
Identification of mutant phenotypes associated with loss of individual microRNAs in sensitized genetic backgrounds in Caenorhabditis elegans
Camera used: CoolSNAP HQ2
Applied Spectroscopy
Multimodal Spectral Imaging of Cells Using a Transmission Diffraction Grating on a Light Microscope
Camera used: CoolSNAP ES2 - June 2011

Cellular and Molecular Bioengineering
Microtubule Tip Tracking and Tip Structures at the Nanometer Scale Using Digital Fluorescence Microscopy
Camera used: CoolSNAP HQ2
Journal of Neuroscience
NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry
Camera used: QuantEM
Blood
Bcl-xL inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
Camera used: QuantEM
PNAS (Proceedings of the National Academy of Sciences)
Replication and segregation of an Escherichia coli chromosome with two replication origins
Camera used: QuantEM
Cell Calcium
Voltage-gated calcium channel types in cultured C. elegans CEPsh glial cells
Multichannel System used: DV2
Journal of Cell Science
A calmodulin-related light chain from fission yeast that functions with myosin-I and PI 4-kinase
Camera used: CoolSNAP HQ2
JCB (Journal of Cell Biology)
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage
Camera used: CoolSNAP HQ2
Cellular Signalling
Dependence on different Rab GTPases for the trafficking of CXCR4 and CCR5 homo or heterodimers between the endoplasmic reticulum and plasma membrane in Jurkat cells
Camera used: CoolSNAP HQ2
PNAS (Proceedings of the National Academy of Sciences)
Chemotactic cell trapping in controlled alternating gradient fields
Multichannel System used: DV2
Journal of Micromechanics and Microengineering
Non-intrusive measurements of transitional and turbulent convective heat transfer in a rectangular microchannel
Camera used: CoolSNAP HQ2
Journal of Neuroscience
Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila
Camera used: CoolSNAP HQ2
JBC (Journal of Biological Chemsitry)
Intracellular CB1 cannabinoid receptors are activated by anandamide
Camera used: CoolSNAP HQ2 - May 2011

JBC (Journal of Biological Chemsitry)
Differential Regulation of the Postsynaptic Clustering of γ-Aminobutyric Acid Type A (GABAA) Receptors by Collybistin Isoforms
Camera used: CoolSNAP HQ2
PNAS (Proceedings of the National Academy of Sciences)
End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment
Camera used: QuantEM
Neurobiology of Disease
Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults
Camera used: CoolSNAP ES2
Journal of Cell Science
Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes
Camera used: Evolve 512
PLoS ONE (Public Library of Science)
Microtubules as Platforms for Assaying Actin Polymerization In Vivo
Camera used: CoolSNAP HQ2
MBoc (Molecular Biology of the Cell)
Phosphatidylinositol-(4, 5)-bisphosphate regulates clathrin-coated pit initiation, stabilization and size
Camera used: CoolSNAP HQ2
Neuroscience
Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice
Camera used: CoolSNAP HQ2
PNAS (Proceedings of the National Academy of Sciences)
Targeting and imaging single biomolecules in living cells by complementation-activated light microscopy with split-fluorescent
Multichannel System used: DV2
JCB (Journal of Cell Biology)
Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk
Camera used: CoolSNAP HQ2 - April 2011

JTH (Journal of Thrombosis and Haemostasis)
Mechanisms underlying FeCl3-induced arterial thrombosis
Camera used: CoolSNAP HQ2
JNC (Journal of Neurochemistry)
Compartment-specific, differential regulation of eukaryotic elongation factor 2 and its kinase within Aplysia sensory neurons
Camera used: QuantEM
Development and Stem Cells
Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate
Camera used: CoolSNAP HQ2
Developmental Biology
Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax
Camera used: CoolSNAP ES2
Analytica Chimica Acta
Patterning pallet arrays for cell selection based on high-resolution measurements of fluorescent biosensors
Camera used: CoolSNAP HQ2
Xenotransplantation
Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection
Camera used: CoolSNAP HQ2
JCB (Journal of Cell Biology)
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
Camera used: CoolSNAP HQ2
Electrophoresis
Hydrodynamic injection with pneumatic valving for microchip electrophoresis with total analyte utilization
Camera used: CoolSNAP ES2
Journal of Neuroscience
Development, Maturation, and Necessity of Transcription Factors in the Mouse Suprachiasmatic Nucleus
Camera used: CoolSNAP HQ2 - March 2011

Journal of Cell Science
Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane
Camera used: CoolSNAP HQ2
JCB (Journal of Cell Biology)
Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins
Camera used: CoolSNAP HQ2
Nucleic Acids Research
Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification
Multichannel System used: DV2
Micro Electro Mechanical Systems (MEMS) International Conference
Dual Q-dot transport on microtubule array with polarity defined by nanotracks and microtubule motility control
Multichannel System used: DV2
Micro Electro Mechanical Systems (MEMS) International Conference
Microfluidic Western blotting: Cationic surfactant based protein sizing integrated with electrostatic immobilization
Camera used: CoolSNAP HQ2
JBC (Journal of Biological Chemsitry)
Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays
Camera used: QuantEM
The Plant Journal
Dynamics of Arabidopsis SUN proteins during mitosis and their involvement in nuclear shaping
Camera used: CoolSNAP HQ2
PLoS ONE (Public Library of Science)
An Improved Cerulean Fluorescent Protein with Enhanced Brightness and Reduced Reversible Photoswitching
Camera used: CoolSNAP HQ2
Yeast
A novel fission yeast mei4 mutant that allows efficient synchronization of telomere dispersal and the first meiotic division
Camera used: CoolSNAP HQ2
MCP (Molecular and Cellular Proteomics)
A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae
Camera used: CoolSNAP HQ2 - February 2011

Development
Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear
Camera used: Evolve 512
RNA
P-body components, Dhh1 and Pat1, are involved in tRNA nuclear-cytoplasmic dynamics
Camera used: CoolSNAP HQ2
New Phytologist
Cellular pH measurements in Emiliania huxleyi reveal pronounced membrane proton permeability
Camera used: CoolSNAP HQ2
Lab on a Chip
Flexible casting of modular self-aligning microfluidic assembly blocks
Camera used: Evolve 512
PNAS (Proceedings of the National Academy of Sciences)
Transient binding of dynein controls bidirectional long-range motility of early endosomes
Camera used: CoolSNAP HQ2
EMBO Journal (European Molecular Biology Organization)
Controlled and stochastic retention concentrates dynein at microtubule ends to keep endosomes on track
Camera used: CoolSNAP HQ2
JBC (Journal of Biological Chemsitry)
Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation
Camera used: QuantEM
Crystal Growth and Design
Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases
Camera used: CoolSNAP HQ2
Neuropharmacology
Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells
Camera used: CoolSNAP ES2
JCB (Journal of Cell Biology)
Cadherin exits the junction by switching its adhesive bond
Camera used: CoolSNAP HQ2
American Journal of Physiology
Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF
Camera used: CoolSNAP HQ2 - January 2011

Methods in Molecular Biology
Toward drug design: recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets
Camera used: CoolSNAP HQ2
Endocrinology
Glutamine Triggers and Potentiates Glucagon-Like Peptide-1 Secretion by Raising Cytosolic Ca2+ and cAMP
Camera used: QuantEM
Glia
Expression of N‐methyl D‐aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF‐κB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats
Camera used: CoolSNAP HQ2
Journal of Bacteriology
The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates
Camera used: CoolSNAP HQ2
JBC (Journal of Biological Chemsitry)
Localization of the PIP2 sensor of TRPV1 ion channels
Camera used: QuantEM
MBoc (Molecular Biology of the Cell)
The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis
Camera used: CoolSNAP HQ2
Nature Methods
Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans
Camera used: CoolSNAP HQ2
JBC (Journal of Biological Chemsitry)
Myosin Va is required for P body but not stress granule formation
Camera used: QuantEM
Gene
High content imaging-based assay to classify estrogen receptor-[alpha] ligands based on defined mechanistic outcomes
Camera used: CoolSNAP HQ2
Biochemical and Biophysical Research Communications
Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39
Camera used: CoolSNAP HQ2
Journal of Cellular Physiology
Voltage-gated K+ channels play a role in cAMP-stimulated neuritogenesis in mouse neuroblastoma N2A cells
Camera used: CoolSNAP HQ2
Journal of Sexual Medicine
Silencing MaxiK Activity in Corporal Smooth Muscle Cells Initiates Compensatory Mechanisms to Maintain Calcium Homeostasis
Camera used: CoolSNAP HQ2
MBoc (Molecular Biology of the Cell)
Dynamic and structural signatures of lamellar actomyosin force generation
Camera used: CoolSNAP HQ2

