Customer Applications

Read how Photometrics customers are using Scientific CMOS (sCMOS) cameras, CCDs, EMCCDs and other imaging solutions to achieve their research goals. Short customer references and in-depth case studies from research organizations around the globe provide insight into imaging techniques used for a multitude of bioresearch applications.

Simultaneous Atomic Force Microscopy, TIRF, and FSD Confocal Microscopy for Live Cell Mechanotransduction Studies - QuantEM™ EMCCD cameras
Calcium Imaging - Evolve 128 EMCCD Camera
Electrophysiology and FRET - Evolve 512 EMCCD Camera & DV2 Multichannel System
Super-Resolution Microscopy (SptPALM/STORM) - Evolve 512 Delta EMCCD Camera
Live Cell Spinning Disk Microscopy of Endogenously Expressed, Low Abundance Proteins - Prime 95B sCMOS Camera, Evolve 512 EMCCD Camera
Confocal Microscopy & Stochastic Optical Reconstruction Microscopy (STORM) - Prime 95B Scientific CMOS Camera
Quantitative Biological Microscopy- volve 512 EMCCD Camera & Evolve 512 Delta EMCCD Camera
Calcium Imaging - Evolve 128 EMCCD Camera
Super-Resolution Microscopy - Evolve 512 EMCCD Camera
Super-Resolution Fluorescence Microscopy - Prime 95B Scientific CMOS Camera
Super-Resolution Microscopy - Evolve 512 EMCCD Camera
Confocal Microscopy & Stochastic Optical Reconstruction Microscopy (STORM) - Prime 95B sCMOS Camera
Browse all references, or refine your search:
Research Applications
Scientific Camera
Institution/Organization
University of Sussex
Compared to the EMCCD, the Prime 95B gives us a field of view large enough for our most demanding experiments as well as faster frame rates.
University of California, Irvine
The reliability and stability of the pixel noise, makes the Prime 95B Scientific CMOS camera an ideal imaging solution for fluorescence correlation spectroscopy methods.
University of York
Better temporal and spatial resolution means better quality data. We’ll definitely be using the Prime 95B Scientific CMOS camera for our upcoming experiments.
University of York
Altogether, there is no better camera for cutting-edge single molecule microscopy than the Prime 95B Scientific CMOS
Max Planck Institute
Using the Iris 9 Scientific CMOS [sCMOS] camera, we are able to record videos of cells in low-light conditions with high enough resolution to identify individual cells, and with high enough speed to resolve their full range of motion with the camera's large field of view.
Ludwig-Maximilian University
The Prime 95B [Scientific CMOS] camera provides the required sensitivity that is needed to image our yeast cells with as little excitation light as possible.
University of Southampton
The Iris 15 [Scientific CMOS camera] gives us the field of view, resolution and sensitivity to use calcium imaging to study interactions between large populations of cells with single-cell resolution on our Mesolens microscope.
Yale University
The quantum efficiency of the camera is a really important factor for us. If we can use less excitation power, we can increase the length of our imaging and minimize photodamage to the animal. The sensitivity of the Prime 95B [Scientific CMOS camera] is truly transformative for our type of work.
University of Michigan
The Prime 95B [Scientific CMOS camera] allowed us to not only increase the frame rate we were using to acquire images, but we also achieved higher resolution. For us, that meant being able to look at subcellular structure in real time.
Suliana Manley Lab
We can now more precisely locate each fluorescent dye that is targeting a protein within a complex [with the Prime 95B Scientific CMOS camera]. This has the effect of improving the resolution of our structural models, allowing us to see details inside these complexes that we could not before.
University College London
The Prime 95B Scientific CMOS [sCMOS] is an outstanding camera, particularly due to its low-noise, high-sensitivity and large field-of-view.
The University of North Carolina
The Prime 95B Scientific CMOS [sCMOS] camera is, right now, the best solution we have found for TILT imaging. Coupling the Prime 95B to the TILT generates an extremely powerful imaging system!
University of Cambridge
The high QE of the Prime 95B [Scientific CMOS camera] will allow us to improve our investigation of protein dynamics and extend single molecule tracking to more challenging samples.
University of Zürich
The high speed and large field of view of the Prime 95B [Scientific CMOS camera] are a massive advantage for our work.
University of California Berkeley
The bigger our field of view and the lower the exposure times are, the more cells we can image overall as less images are needed and the acquisition is faster [using the Prime 95B Scientific CMOS camera].
University of Cambridge
I find the performance of the Prime 95B [Scientific CMOS camera] to be comparable to state-of-the-art EMCCDs
University of California Berkeley
Camera used: Prime sCMOS and DVΛ
The Prime sCMOS camera and the Dual View λ helped us to collect high quality fiber photometry calcium signals at multiple brain areas at the same time.
University of Colorado
Imaging twice as fast with the Prime 95B [Scientific CMOS camera] is a great advantage. The reduction of pixel-to-pixel variance and the reduction of visible column structure in the camera greatly improves our results.
University of Manchester
The Prime 95B [Scientific CMOS camera] is the perfect camera for Spinning Disk - the image quality is a big improvement over our EMCCDs, and the field of view makes samples much easier to find.
New York University
If you have a shorter exposure time, you can track faster kinetics. More sensitivity and shorter exposure times with the Prime 95B [Scientific CMOS camera] allow you to image faster and track kinetics better.
Korea University
For single-molecule images like in DNA-PAINT, the Prime 95B [Scientific CMOS camera] combined with PrimeEnhance allows us to conduct super-resolution imaging with higher spatial resolution than that of EMCCD technology.
University of Pittsburgh
I think the Prime 95B [Scientific CMOS camera] is a very innovative product. Partly because of the back thinning but also because the pixel size is more appropriate than conventional Scientific CMOS cameras.
deMello Group, ETH Zürich (Switzerland)
The Prime 95B [Scientific CMOS camera] allowed us to acquire high contrast fluorescence images using low excitation intensities, and subsequently allowed us to image over longer periods of time and at higher frequencies than previously possible. This allowed for intrusion-free study of many sensitive developmental processes.
Imperial College London
The Prime 95B camera is specified to provide >95% quantum efficiency, giving us the advantages of Scientific CMOS [sCMOS] with fantastic sensitivity.
University of Lund, Sweden
I don't think I’d use an EMCCD again, I don’t know why I'd use it with the performance we get out of the Prime 95B [Scientific CMOS camera].
University of Cambridge
Camera used: Prime sCMOS
We chose the Prime [sCMOS] camera because it provides very high signal sensitivity while minimizing noise. Prime gives us the signal to noise improvement we needed.
University of Heidelberg, Germany
Photometrics cameras are reliable with great performance. We can now visualize things what we could not see before [with the Prime 95B Scientific CMOS camera].
University of California Berkeley
[Prime 95B Scientific CMOS camera] allows us to conduct our STORM experiments with higher frame rates… 95 percent quantum efficiency allows for super-resolution imaging that’s not achievable with conventional sCMOS cameras.
SALK Institute for Biological Studies
The Prime 95B [Scientific CMOS camera] provides the speed, field of view and resolution of a CMOS camera, with the added sensitivity of an EMCCD camera for our more demanding experiments.
Suliana Manley Lab
Camera used: Prime sCMOS
The real-time filtering and high frame rates of the Photometrics Prime sCMOS camera enable us to capture even more super-resolution microscopy data and to better characterize variability in the structure of chromatin.
Institute for Nutritional Sciences
Cameras used: Evolve 512 EMCCD and DV2
We are very satisfied with the high quantum efficiency of the Photometrics cameras, and we enjoy the flexibility and possibilities of the combined system since all instrumental drivers are compatible with µManager software.
Xiamen University
Camera used: Evolve 128 EMCCD
Evolve 128 helps us monitor the signal fluctuation much more quickly… its great sensitivity guarantees a good signal to noise ratio in such high speed acquisitions.
University of Oxford
Camera used: Evolve 128 EMCCD
The Evolve 128 is very reliable and easy to use. It has proven to be an ideal camera for our demanding temporal requirements.
Indian Institute
Camera used: Evolve 512 EMCCD
The remarkable sensitivity and the ease with which the Evolve 512 camera can be calibrated has been of tremendous practical value to our research
Institute of Biophysics
Camera used: Evolve 512 EMCCD
The Evolve 512 is a very stable camera and provides the high level of accuracy we need for our super-resolution microscopy research.
Indian Institute of Science
The Evolve 512 Delta is great for stochastic super-resolution microscopy and meets our expectations in both ensemble and single molecule microscopy
National Cerebral and Cardiovascular Center
Camera used: Evolve 512 EMCCD
The quality and speed of the Evolve 512 EMCCD Camera has enabled us to capture zebrafish embryo development under challenging conditions.
Johns Hopkins University
Camera used: Evolve 512 EMCCD
Due to the phototoxicity and speed of imaging, the Evolve is essentially running at single-molecule sensitivities in our experiments. We conducted side-by-side camera comparisons… Only the Evolve 512 was suitable for this research.
The University of Glasgow
Cameras used: Evolve 512 EMCCD and DV2
We've been very happy with both the cameras' performance and the excellent technical support provided by Photometrics.
University of Sussex
Camera used: Evolve 512 EMCCD
The Evolve 512 EMCCD camera has performed exceedingly well under challenging and photon-poor conditions.
Peking University
The Evolve EMCCD cameras provide high quality images for quantitative analysis, and have fast image acquisition speed. The cameras are very stable, fast and efficient.
University of Nebraska
The Evolve 512 Delta EMCCD camera has saved us a lot of time and we have much better resolution within our experiments.
National Centre for Biological Sciences (NCBS)
Camera used: Evolve 512 EMCCD
The Evolve's high sensitivity and dynamic range were integral to the acquisition of high-quality images for analysis.
University of Manchester
Camera used: Evolve 128 EMCCD
The Evolve 128's extreme sensitivity and fast read out enables us to detect very small changes in the fluorescence signal.
Kyoto University
Camera used: Evolve 512 EMCCD and DV2
The scientific imaging solutions from Photometrics has made evolutional progress on our electrophysiology and FRET research applications.
Flinders University
We would summarize our experience with Photometrics' personnel and the quality of their cameras as outstanding.
Harvard Medical School
Camera used: Evolve 128 EMCCD
The Evolve 128 EMCCD camera enables me to perform a very difficult experiment on a routine basis that would otherwise be impossible.
Chinese Academy of Sciences
Camera used: Evolve 512 EMCCD
The Evolve 512 is a very stable camera and provides the high level of accuracy we need for our super-resolution microscopy research.

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Case Studies

Imaging the Worlds Brightest Luminescent Protein
Imaging the World's Brightest Luminescent Protein

Takeharu Nagai, PhD, Department of Biomolecular Energetics, Institute of Scientific and Industrial Research at Osaka University

Multi-Parametric Electrophysiological Imaging of the Mammalian Heart In Vivo
Multi-Parametric Electrophysiological Imaging of the Mammalian Heart In Vivo

Peter Lee, Doctoral Student in the Department of Physics at Oxford University and Dr. Christopher Woods, M.D. Ph.D., Division of Cardiovascular Medicine at Stanford University

Single-Camera, Multi-Parametric Imaging of Human Stem Cell-Derived Heart Tissue
Single-Camera, Multi-Parameter Imaging of Human Stem Cell-Derived Heart Tissue

Peter Lee, Doctoral Student at Oxford University and Todd Herron, Assistant Research Professor in the Department of Molecular & Integrative Physiology and Center for Arrhythmia Research at University of Michigan

In Vivo Fluorescence Imaging of Microvasculature
In Vivo Fluorescence Imaging of Microvasculature

Waleed Gaber, associate professor at Baylor's College of Medicine and co-director of the small animal imaging facility at Texas Children's Hospital

Ratiometric Imaging of Fluorescence and Absorption Signals
Ratiometric Imaging of Fluorescence and Absorption Signals

Daryl W. Hochman, Ph.D., Assistant Professor in the Departments of Surgery and Pharmacology and Cancer Biology at Duke University

Simultaneous Atomic Force Microscopy, TIRF, and FSD Confocal Microscopy for Live Cell Mechanotransduction Studies
Simultaneous Atomic Force Microscopy, TIRF, and FSD Confocal Microscopy for Live Cell Mechanotransduction Studies

Andreea Trache, Ph.D., Assistant Professor at Texas A&M Health Science Center