Prof. Mark Leake
Professor Anniversary Chair of Biological Physics
University of York
Prof. Leake founded and leads the Biological Physical Sciences Institute at the University of York, which brings together scientists researching the biomolecular interactions, biological modelling imaging and quantitation of complex data. His work targets a broad range of fundamental processes and open questions in biology, and has provided insight into topics such as the behavioural mechanics of the ﬂagellar motor of bacteria, protein transport, DNA replication, repair and remodelling, signal transduction, gene regulation and oxidiative phosphorylation.
Prof. Leake’s lab is at the forefront of developing new biophysical instrumentation to probe cells and biological specimens on a single-molecule level. Single-molecule imaging is a hugely powerful cutting-edge technique for examining fundamental processes and interactions in biological systems. However, the technique is also among the most demanding low-light imaging applications, as the ﬂuorescent response from a single ﬂuorophore is very low, and photobleaching must be avoided. Determining the precise quantity and localisation of single-molecule signals requires an excellent signal to noise ratio for the weakest of signals, while simultaneously delivering high spatial and temporal resolution.
Altogether, there is no better camera for cutting-edge single molecule microscopy than the Prime 95B Scientific CMOS