Physics and Biophysics

Physics and Biophysics

Physics imaging encompasses a wide range of techniques used to interrogate physical phenomena using high tech imaging systems. Biophysics involves using the theories and methods of physics to study biological systems, with biophysical imaging contributing to drug discovery, structure and function of biological molecules, and how cells and molecules interact.

For physics and biophysics imaging, researchers rely on highly sensitive and non-invasive analysis techniques. A number of which are fluorescence-based, but also including light scattering or spectroscopy-based techniques.

Most biophysical imaging techniques require cameras with high sensitivity and fast speeds in order to detect the molecular events occurring within the sample.

Kinetix photo

Kinetix

High sensitivity, 95% quantum efficient sCMOS camera with an incredibly high 400 fps full-frame speed and a massive 29.4 mm diagonal field of view.

The speed of the Kinetix significantly outperforms typical sCMOS devices. With a full-frame framerate of 400 fps and a 10 megapixel sensor, the Kinetix delivers over 4000 megapixels/second

The high quantum efficiency and low read noise combined with the balanced 6.5 µm pixel size also delivers the sensitivity needed to get the highest image quality from biophysical systems without sacrificing resolution.

Prime BSI Express Camera

Prime BSI Express

High sensitivity, 95% quantum efficient, sCMOS camera with 6.5 µm pixels,
1.0 e read noise and 95 fps full frame speed.

The high quantum efficiency and low read noise combined with the balanced 6.5 µm pixel size offers high sensitivity imaging whilst achieving Nyquist sampling with the most popular objective magnifications used for biophysical imaging.

Prime 95B

Extremely sensitive, 95% quantum efficient sCMOS camera with 11 µm pixels and EMCCD level detection.

Go beyond EMCCD for biophysical imaging with the back-illuminated Prime 95B, which features an equivalent level of detection but with a faster speed, larger field of view and no EM-gain aging or excess noise.

The Prime 95B allows exposure times to be lowered significantly to increase acquisition speed and reduce photobleaching and photodamage to the lowest levels possible on an sCMOS camera.

Customer Stories

FRET Voltage Imaging

Professor Jiulin Du Chinese Academy of Sciences (CAS), Shanghai Rev

“Compared to other EMCCD and sCMOS cameras, the Prime 95B can detect very dim signals, achieving a high signal-to-noise ratio and fast imaging rate, giving good spatiotemporal resolution.”

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Single Molecule Micromirror TIRF

Prof. Karl Duderstadt Max-Planck Institute of Biochemistry

“The chip size is large, giving us a large field of view, which is really fantastic, and the pixel size is small at 6.5 microns, which permits Nyquist matching on our 60x lens, maximizing resolution in our experiments.”

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Single Molecule Imaging

miCube (dSTORM) images
Dr. Johannes Hohlbein Hohlbein Laboratory of Biophysics

“The 95% quantum efficiency of the back-illuminated sensor ensures that almost all photons arriving at the camera are collected which is of great benefit for our lowest light applications.”

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