By bringing the light in from the back of the sensor, photons land directly onto the light receiving surface, maximizing light collecting capability. Improved sensitivity is of paramount importance for applications where every photon counts, such as TIRF, single molecule imaging, PALM/STORM localization microscopy and spinning disk confocal microscopy.
Extreme Field of View
Larger format sensors are designed to maximize the amount of data captured and take full advantage of new, larger field of view microscopes. Increasing throughput through field of view improvement is extremely desirable for applications such as high content screening, light sheet microscopy and large tissue imaging.
Superior Background Quality
Photometrics uses its Pattern Noise Reduction Technology and Correlated Noise Reduction Technology to ensure every Scientific CMOS camera delivers clean, pattern free images with minimal pixel defects, delivering improved image quality at the low end.
The clean backgrounds and control of correlated noise lead to improvements when using advanced algorithms for applications such as PALM/STORM, SRRF, SIM and FCS.
Unmatched Signal to Noise Ratio
Prime Enhance active denoising1 provides a real-time quantitative increase in the signal to noise ratio by reducing the effects of photon shot noise at low light levels. By increasing the effective signal to noise, it is possible to acquire higher quality images at lower exposure times, reducing the effects of phototoxicity and photobleaching on samples.
Increasing signal to noise in low-light samples is of great interest for applications such as PALM/STORM, single molecule imaging and spinning disk confocal microscopy.
Live Particle Tracking
Live particle tracking1 on the camera takes a technique typically performed in post-processing and delivers it live, with live statistics.
The ability to perform particle tracking live on the camera is a fantastic tool to give early insight into the kinetics of moving molecules for single molecule tracking applications.
Data Reduction Technology
Photometrics is committed to developing ways of overcoming this issue and currently offers two data reduction technologies; PrimeLocate and Multi-ROI.
PrimeLocate locates the 500 brightest pixels and only transfers this data. This technology couples perfectly with localization microscopy techniques such as PALM, STORM and DNA-PAINT which rely on identifying only a few active regions per frame.
Multi-ROI lets the user select multiple regions of interest on the frame. Perfect for when areas of interest are spaced far away. Also, just like setting a single region of interest, this technology increases acquisition speed.