PRIME BSI95% Quantum Efficiency

The Prime BSI Scientific CMOS (sCMOS) camera delivers the perfect balance between high resolution imaging and sensitivity with an optimized pixel design and near perfect 95% Quantum Efficiency.

  • 95% Quantum Efficiency
  • 6.5 µm x 6.5 µm Pixel Area
  • 1 e- Read Noise

Key Features

QE Curve


The Prime BSI back-illuminated sCMOS camera achieves a near-perfect 95% quantum efficiency. By bringing the light in from the back of the sensor, photons land directly onto the light receiving surface, maximizing light collecting capability. The Prime BSI combines 95% quantum efficiency with a low 1.0 e- read noise to deliver the most sensitive camera based on sCMOS technology at over 40 frames per second.

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Testes application image

Resolution and Pixel Size

The Prime BSI features 6.5 μm pixels, the accepted standard for most live cell applications using 40x and 60x magnification. This pixel size provides highly detailed images across the imaging plane and is most suitable for the broadest range of microscope objectives.

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Superior Background Quality

The Prime BSI features Pattern Noise Reduction Technology and Correlated Noise Reduction Technology to ensure that it delivers clean, pattern free images with minimal pixel defects, delivering improved image quality in low light conditions.

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Programmable Scan Mode image

Advanced Triggering

Programmable Scan Mode provides increased control over the rolling shutter exposure and read-out functionality of CMOS sensors for applications that require control over the line time.

Sequenced Multiple Acquisition Real Time Streaming (SMART) Streaming enables the Prime BSI to capture a continuous sequence of images while cycling through 16 pre-programmed exposure time values, delivering the fastest multi-channel acquisition times.

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Advanced Features

The Prime BSI offers PrimeEnhance active denoising which provides a real-time quantitative increase in the signal to noise ratio to maximize sensitivity at ultra-low light levels.

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Family Specifications

Sensor Technology sCMOS
Quantum Efficiency 95%
Pixel Size 6.5 µm x 6.5 µm
Supported Interfaces PCIe and USB 3
Spectrum Capabilities UV (200-400 nm), Visible (400-700 nm)
Near Infrared (700-1000 nm)
Read Noise (median) 1.0 e-
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Camera Models

Sensor Area
Frame Rate
Prime BSI
Sensor Area
13.3 mm x 13.3 mm
18.8 mm diagonal
Frame Rate
43 fps @16-bit /
63 fps @ 11-bit



Customer Stories

Single Molecule DNA Imaging

Jonathan Jeffet University of Tel-Aviv, Israel

“The [Prime BSI] was really quick and easy to set up and worked well with MicroManager, and we’re happy because we’re seeing better results, the SNR is really better, it’s perfect for our needs”

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Single Molecule Tracking

Prof. Ulrich Kubitscheck The University of Bonn

“With the Prime BSI the signal-to-noise ratio is much better, and simultaneously the field of view is huge compared to the previous EMCCD.”

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High-Resolution Time-Lapse Imaging

Cees Dekker Group Delft University of Technology

“We previously used to image in a single plane but now we can take z-stacks through the liposome with high enough frame rates to visualize the internal dynamics”

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