PRIME BSI95% Quantum Efficiency

The Prime BSI Scientific CMOS (sCMOS) camera delivers the perfect balance between high resolution imaging and sensitivity with an optimized pixel design and near perfect 95% Quantum Efficiency.

  • 95% Quantum Efficiency
  • 6.5 µm x 6.5 µm Pixel Area
  • 1 e- Read Noise

Key Features

QE Curve


The Prime BSI back-illuminated sCMOS camera achieves a near-perfect 95% quantum efficiency. By bringing the light in from the back of the sensor, photons land directly onto the light receiving surface, maximizing light collecting capability. The Prime BSI combines 95% quantum efficiency with a low 1.0 e- read noise to deliver the most sensitive camera based on sCMOS technology at over 40 frames per second.

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Testes application image

Resolution and Pixel Size

The Prime BSI features 6.5 μm pixels, the accepted standard for most live cell applications using 40x and 60x magnification. This pixel size provides highly detailed images across the imaging plane and is most suitable for the broadest range of microscope objectives.

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Superior Background Quality

The Prime BSI features Pattern Noise Reduction Technology and Correlated Noise Reduction Technology to ensure that it delivers clean, pattern free images with minimal pixel defects, delivering improved image quality in low light conditions.

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Programmable Scan Mode image

Advanced Triggering

Programmable Scan Mode provides increased control over the rolling shutter exposure and read-out functionality of CMOS sensors for applications that require control over the line time.

Sequenced Multiple Acquisition Real Time Streaming (SMART) Streaming enables the Prime BSI to capture a continuous sequence of images while cycling through 16 pre-programmed exposure time values, delivering the fastest multi-channel acquisition times.

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Advanced Features

The Prime BSI offers PrimeEnhance active denoising which provides a real-time quantitative increase in the signal to noise ratio to maximize sensitivity at ultra-low light levels.

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Family Specifications

Sensor Technology sCMOS
Quantum Efficiency 95%
Pixel Size 6.5 µm x 6.5 µm
Supported Interfaces PCIe and USB 3
Spectrum Capabilities UV (200-400 nm), Visible (400-700 nm)
Near Infrared (700-1000 nm)
Read Noise (median) 1.0 e-
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Camera Models

Sensor Area
Frame Rate
Prime BSI
Sensor Area
13.3 mm x 13.3 mm
18.8 mm diagonal
Frame Rate
43 fps @16-bit /
63 fps @ 11-bit



Customer Stories

Single Molecule Imaging

Single-Molecule Fluorescence Imaging
Dr. Steven Lee University of Cambridge

“The Prime BSI Back-illuminated sCMOS gives EMCCD-level sensitivity at high frame rates and with a very large field of view, speeding up our single molecule tracking acquisition.”

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Single Molecule Imaging

Multifocal two-photon image of gold nanorods randomly dispersed on a glass coverslip.
John van Noort Group Leiden University

“The low readout noise, high quantum efficiency and large sensor size makes the Prime BSI all we need from a camera.”

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Super Resolution Standing Wave Microscopy

Super Resolution
Prof. Gail McConnell University of Strathclyde

“The Prime BSI, with a 6.5 µm pixel, offers the most flexibility for use with the range of objectives we are using as well as improving the resolution.”

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